Mass Effect 3 will be supported by Kinect and will allow players to control their squad via voice commands;
"Liara singularity, Kaiden Cover Concussion Shot, etc"
Also with Kinect support Mass Effect 3 will use your voice for Commander Shepard's role. You can speak your own lines and immerse yourself in Bioware's popular trilogy.
Melee combat was shown off briefly as Commander Shepard has a new tech-blade and is deadly accurate with it.